Extáze
Extáze (Ecstasy, X, E, Adam, XTC, M&M) Byla patentována 1913 německou firmou MERCK, a dokud nebyla zakázána (v Anglii 1977, v USA 1985), běžně se prodávala v barech a klubech. MDMA má široké spektrum použití. Je to stimulant, spojený dnes hlavně s tancem na "rave parties", používá se jako náhrada za Speed (koncentrace, motivace, kreativita, energie). Ne méně důležitý je však její vliv na psychiku, díky němuž byla léta používána k psychoterapii, který spočívá v produkování stavů entaktogeneze a empatogeneze. Entaktogeneze - všechno se světem se zdá dobré a v pořádku, člověk vnímá pocity "míru" a radosti. Souznění se vším tvorstvem, matkou Zemí Gaiou. Obvyklé věci se mohou zdát abnormálně krásné a zajímavé. Empatogeneze je vytváření stavů empatie. MDMA je díky tomu známa jako "hug drug", droga objímání. Jsou zažívány pocity emocionální blízkosti k druhým (a k sobě), spolu se zhroucením komunikačních bariér je potom snadné otevřít se, hovořit s ostatními. Mnoho lidí vyhledává MDMA právě k tomuto účelu: "Konverzace proudí jako voda. Víte přesně co říct a kdy to říct." MDMA zřetelně zesiluje smyslové vnímání - chuť, hmat, čich, zrak. Intoxikovaní se často dotýkají různých povrchů (kůže, navzájem), ochutnávají jídla a nápoje. Dotyk a osobní kontakt (sexuální i jiný) se díky emocionální blízkosti subjektů může stát intenzivně příjemným.
POUŽITĺ
Míchání s účinky marihuany či LSD (známé jako "XL", většina dává přednost nižším dávkám) je zdá se přípustné, nikoli tak se sedativy (Heroin, lkohol - dehydratace) nebo dalšími stimulanty (Kokain, amfetaminy). Smrt nastává v kombinaci s MAO inhibitory. Obvyklá dávka je 80 - 160 mg perorálně (přibl. 2 mg/kg). Efekty se dostaví po 30 až 45 minutách, dosahují maxima po 1 - 1.5 h. Zde se pro prodloužení tripu bere 1/3 až 1/2 původní dávky. Po dalších 2 hodinách se jinak začínají vytrácet. Po mnoha dávkách může MDMA pro někoho "ztratit svoje kouzlo", nepomáhá ani dlouhodobá přestávka. Příčiny jsou pravděpodobně spíše psychologické než neurofyziologické.
CHEMIE
MDMA (3,4-methylendioxymetamfetamin) je polosyntetický bílý krystalický prášek, chemicky blízký metamfetaminům.
PŮSOBENĺ
Zvyšuje krevní tlak a puls, sucho v ústech, skřípání zubů, nystagmus, nausea. Ve vyšších dávkách (předávkování) jsou příznaky podobné jako u amfetaminů: závratě, hyperkardie, nervozita. Ve vyvolané euforii lze snadno ignorovat příznaky nebezpečné dehydratace nebo přehřátí, vedoucí ke ztrátě vědomí, hospitalizaci, v horších případech k smrti. Postiženého je nutné zchladit, podávat vodu a ovocné nápoje, nikoli alkohol. MDMA též patrně způsobuje snížení hladiny serotoninů v mozku (udává se až o 30%), což by možná mohlo být příčinou objevujících se depresivních stavů. Bránit se lze používáním vitamínů. Neurotoxické změny i přes masové používání nejsou prokázány (výzkumy se prováděly pouze na laboratorních zvířatech). Příbuzné látky: MDA (3,4-methylendioxyamfetamin) byla populární krátce v 70. letech jako "droga lásky"; přízvisko se někdy používá i pro MDMA. Má větší stimulační účinky a je více toxická. MDE, MDEA (N-ethyl-methylendioxyamfetamin), často nazývána "Eva", má podobné účinky, méně komunikativní a emoční, více intelektuální. MMDA (3-methoxy-4,5-methylendioxyamfetamin) působí zajímavé halucinace při zavřených očích, vědomé sny.
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